Endocrine Abstracts

Autoimmune thyroiditis (AT) may occur as a single disease or associated with further endocrine and non endocrine autoimmune diseases (NEAD). Chronic autoimmune gastritis (CAG) is the more frequently associated NEAD. A prevalent Th1-representative pattern of cytokines and chemokines has been described in isolated autoimmune thyroiditis. However, the behaviour of chemokines when AT is associated with CAG is not known. Aim of the study has been to measure serum levels of CXCL10 i...

Introduction: No study has evaluated the effect of cytokines on the prototype beta chemokine (C-C motif) ligand (CCL)2 in Graves’ ophthalmopathy (GO), nor of peroxisome proliferator-activated receptor (PPAR)alpha activation on this chemokine secretion in fibroblasts or preadipocytes in GO.Design and methods: We have tested the interferon (IFN)gamma and tumor necrosis factor (TNF)alpha effect on CCL2, and for comparison on the prototype alpha chemoki...

Introduction: The antitumor activity of a novel cyclic amide, CLM94, with anti-VEGFR-2 and antiangiogenic activity, in primary anaplastic thyroid cancer (ATC) cells in vitro and in vivo, has been studied.Design and Methods: CLM94 was tested: i) in two human cell lines (HMVEC-d, dermal microvascular endothelial cells; 8305C, undifferentiated thyroid cancer) at 0.001–100 mcM; ii) in ATC cells at the concentrations of 10, 30, 50 mcM; iii)...